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The 23rd Annual Meeting of the Groups Studying the Structures of AIDS-Related Systems and Their Application to Targeted Drug Design 06/25/2009 to 06/26/2009
Lister Hill Auditorium
Bethesda, Maryland
HIV-Host interaction network based on data in the NIAID HIV1-Human Protein Interaction Database (http://www.ncbi.nlm.nih.gov/projects/RefSeq/HIVInteractions/). HIV proteins are shown in red, host proteins are yellow. Image provided courtesy of the HARC Center (http://harc.ucsf.edu).

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The 23rd Annual Meeting of the Groups Studying the Structures of AIDS-Related Systems and Their Application to Targeted Drug Design

06/25/2009 - 06/26/2009

THURSDAY, JUNE 25
 
 
8:30 – 8:35              Ravi Basavappa (National Institute of General Medical Sciences)
                              Welcome / Opening Remarks
 
8:35 – 9:45              Chris Aiken (Vanderbilt University), Angela Gronenborn(University of Pittsburgh) and Joanne Yeh (University of Pittsburgh)
                              The Pittsburgh Center for HIV Protein Interactions: New insights into HIV-1 capsid - molecular interfaces from cryoEM, NMR, and X-ray structures aid in explaining functional analyses
 
 
9:45 – 10:55            Wes Sundquist (University of Utah)
CHEETAH Center Overview and Studies of Lentiviral Uncoating and TRIM5alpha Restriction

Mark Yeager (University of Virginia and The Scripps Research Institute)
Structure of the Hexameric Building Block of the HIV-1 Capsid

Chris Hill (University of Utah)
Structural and Functional Studies of Host Proteins Involved in HIV Budding
 
 
10:55 - 11:15           BREAK
 
 
11:15 – 12:25          Alan Frankel (University of California, San Francisco)
                              HARC Center Overview and Progress on Tat and Rev Complexes
 
                              Nevan Krogan (University of California, San Francisco)
                              Global Characterization of HIV-Human Protein-Protein Interactions
 
                              John Gross (University of California, San Francisco)
                              An Expanded Nedd8 Cascade is Required for Activation of the Vif E3 Ligase
 
                              Yifan Cheng (University of California, San Francisco)
                              Structure of HIV-1 Envelope Glycoprotein Complex by Single Particle cryo-EM
 
 
12:25 – 1:30            LUNCH
 
 
1:30 – 3:30              POSTER SESSION
 
 
3:30 – 4:00              Dana Gabuzda (Dana-Farber Cancer Institute)
                              High–Throughput Screen for Small Molecule Inhibitors of HIV Vif-APOBEC3G Interaction
 
4:00 – 4:30              Joseph Wedekind (University of Rochester)
                              Evidence for Dimerization of the Innate Antiviral Factor APOBEC3G and Crystallization of the HIV-1 Vif Protein
 
4:30 – 5:00              Kevin Weeks (University of North Carolina – Chapel Hill)
                              The Architecture and Secondary Structure of an Entire HIV-1 RNA Genome
 
5:00                        Adjourn for day
 
 
 
 
FRIDAY, JUNE 26
 
 
Special session on single particle/single cell analysis of viral systems
 
8:30 – 9:00              Sanford Simon (The Rockefeller University)
                              Visualizing the Biogenesis of Individual HIV-1 Virions in Live Cells
 
9:00 – 9:30              Xiaowei Zhuang (Harvard University / Howard Hughes Medical Institute)
A Molecular Gymnast: The HIV Reverse Transcriptase
 
9:30 – 10:00            Antoine van Oijen (Harvard Medical School)
                              Visualizing Viral Fusion at the Single-Particle Level
 
10:00 – 10:30          Leor Weinberger (University of California, San Diego)
                              ‘Noise-Imaging’ to Map the Gene Regulatory Circuits of Viruses
 
 
10:30 – 10:50          BREAK
 
 
10:50 – 11:20          Peter Kwong (National Institute of Allergy and Infectious Diseases)
                              Structure of HIV-1 gp120 with gp41-Interactive Region: Layered Architecture and Basis of Conformational Mobility
 
11:20 – 11:50          Michael Summers (University of Maryland, Baltimore County and Howard Hughes Medical Institute)
                              Structural Basis for Trafficking of HIV-1 and HIV-2 Proteins to Virus Assembly Sites
 
11:50 – 12:20          Giovanni Cardone (National Institute of Arthritis and Musculoskeletal and Skin Diseases)
                              Structural Analysis of Pentamer-containing Assemblies of Retrovirus Capsid Proteins
 
 
12:20 – 1:20            LUNCH/POSTER SESSION
 
 
1:20 – 2:00              Celia Schiffer (University of Massachusetts Medical School)
                              Targeting Drug Resistance in HIV-1 Protease
 
2:00 – 2:40              Irwin Chaiken (Drexel University)
Overview of HIV-1 Envelope gp120 Antagonism Project and Progress on Peptide Conjugate Allosteric Inhibitors
 
Judith LaLonde (Bryn Mawr College)
Virtual Screening for gp120 Small Molecule Inhibitors
 
Matthew Le-Khac (Columbia University)
Structure Analysis of CD4-mimetic Compounds Bound to HIV gp120
 
2:40 – 3:20              Arthur Olson (The Scripps Research Institute)
                              Resistance Driven Structural Design for HIV Therapeutics – Program Overview
 
                              C.D. Stout (The Scripps Research Institute)
Fragment-Based Screen against HIV Protease: Crystallographic Evidence for Two Allosteric Binding Sites
 
Bruce Torbett (The Scripps Research Institute)
Resistance-Driven Approaches to HIV Protease Inhibition:
Structure and Biology
 
Richard Belew (University of California, San Diego)
Incorporating Hypermutation Into Computational Models Of HIV Resistance Evolution In Protease
 
 
3:20 – 3:40              BREAK
 
 
3:40 – 4:05              T.N. Bhat (National Institute of Standards and Technology)
                              Structural Database Using Semantic Web concepts to Support Structure-Based Drug Design for AIDS and Other Diseases such as Cancer and Malaria
 
4:05 – 4:30              Martin Schiller (University of Connecticut Health Center)
                              MnM-HIV, an Interactive Webtool for Identifying New Functional Motifs in HIV Proteins
 
4:30 – 4:55              Xiaowu Chen (Gilead Sciences)
                              Modeling Binding Modes of HIV Integrase Inhibitors
 
4:55 – 5:20              David Green (Stony Brook University)
                              Protein Engineering of Virucidal Lectins Targeting HIV
 
5:20                        Adjourn Meeting
 

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