Agenda

The 25th Annual Meeting of the Groups Studying the Structures of AIDS-Related Systems and Their Application to Targeted Drug Design

03/28/2011 - 03/30/2011
 

The 25th Annual Meeting of the Groups Studying the Structures of AIDS-Related Systems and Their Application to Targeted Drug Design 

Day 1 – March 28, 2011  

8:00-8:30      Light refreshments

8:30-8:35      Welcome/Opening Remarks – Joe Gindhart, Jeremy Berg

8:35-9:20        Steve Harrison, Harvard Medical School/HHMI

Keynote Address: Structural biology of HIV/AIDS: accomplishments and perspectives

Morning session- HIV life cycle (Angela Gronenborn, Moderator)

9:20-10:10      Angela Gronenborn Pittsburgh Center for HIV-Protein Interactions

10:10-10:35    Bing Chen, Harvard Medical School, Rational design of an effective HIV-1 gp41-based immunogen

10:35-10:55  Break

10:55-11:20    Eddy Arnold, Rutgers University, Reverse transcriptase drug design and drug resistance

11:20-11:45    Alan Engelman, Dana-Farber Cancer Institute, Structural biology of HIV-1 integration

11:45-12:10    Tahir Tahirov, University of Nebraska Medical Center, Exploration of P-TEFb-Tat complex structure for the design of Conditionally Anchored Smart Inhibitors

12:10-12:35    Mike Summers, University of Maryland, Baltimore County, New insights into the mechanism of HIV-1 genome selection and packaging

12:35-1:30    Lunch

1:30-2:30      Posters

Afternoon session- HIV host-pathogen interactions (Wes Sundquist, Moderator)

2:30-3:20        Wes Sundquist Center for the Structural Biology of Cellular Host Elements in Egress, Trafficking, and Assembly of HIV

3:20-3:45        Reuben Harris, University of Minnesota, Critical Interactions of APOBEC3s: Molecular Approaches to Novel HIV Therapies

3:45-4:05      Break

4:10-5:00        Alan Frankel HARC Center: HIV Accessory and Regulatory Complexes

5:00-5:25        Irwin Chaiken, Drexel University College of Medicine, Attacking the HIV-1 entry machine         

5:20                 Adjourn

 

Day 2 – March 29, 2011

8:00-8:30      Light refreshments

8:30-8:55      Perspectives on NIGMS AIDS program and its future

Morning session - Imaging HIV (Wah Chiu, Moderator)

8:55-9:20        Wah Chiu, Baylor College of Medicine, Structural morphogenesis from assembly to maturation of dsDNA virus

9:20-9:45        Grant Jensen, California Institute of Technology, Electron cryotomographic studies of HIV-1

9:45-10:10      Tom Hope, Northwestern University, Cell biology of HIV

10:10-10:30  Break

10:35-11:00    John Guatelli, UCSD School of Medicine, Restriction of virion release by BST2/tetherin and it counteraction by HIV-1 Vpu

11:20-11:45    Sriram Subramaniam, NCI Center for Cancer Research, Molecular architecture of HIV envelope glycoproteins and mechanisms of cellular entry

11:45-12:45    Lunch

Afternoon session-Latency (John Coffin, Moderator)

12:45-1:10      John Coffin, Tufts University School of Medicine, Persistence and diversity of HIV in natural and ART-induced control of infection

1:10-1:35        Leor Weinberger, University of California San Diego, Novel therapies against HIV

1:35-2:00        Robert Siliciano, Johns Hopkins University School of Medicine, Quantitative analysis of the efficacy of antiretroviral drugs:  How HAART really works

2:00-2:25        David Margolis, University of North Carolina at Chapel Hill, Targeting silent HIV genomes:  the next frontier

2:25-2:30      Goal for breakout discussion groups – Peter Preusch (NIGMS)

2:25-2:45        Break 

2:45-3:45      Breakout discussion groups: The future of NIGMS HIV research

2:45-5:30      Posters

3:45-4:45      Science Advisory Board Meeting

4:45-5:45      Discussion of issues raised in breakout groups

5:45                Adjourn        

 

Day 3 – March 30, 2011

8:00-8:30      Light refreshments

Morning session I- Viral Host Recognition (Peter Kwong, Moderator)

8:35-9:00        Peter Kwong, NIAID Vaccine Research Center, VRC01, structural biology, and HIV-1 vaccine design

9:00-9:25        Joe Sodroski, Dana-Farber Cancer Institute, Understanding early events in HIV infection

9:25-9:50        Ian Wilson, The Scripps Research Institute, Broadly neutralizing antibodies to HIV-1

9:50-10:15      Pamela Bjorkman, California Institute of Technology/HHMI, Engineering immunity against HIV 

10:15-10:40    David Spiegel, Yale University, Building HIV immunity using small molecules

10:40-10:50    Break

Morning Session 2- Structure-Based Drug Design and Resistance (Celia Schiffer, Moderator)

10:50-11:15    Celia Schiffer, University of Massachusetts Medical School, Combating drug resistance:  Lessons from HIV-1 protease and beyond

11:15-11:40    Art Olson, The Scripps Research Institute, New approaches to HIV protease drug resistance

11:40-12:05    Alex Wlodawer, NCI Macromolecular Crystallography Laboratory, It is not only HIV – the impact of crystallographic studies of retroviral proteases on understanding their specificity and drug resistance

12:05-12:30    Manuel Navia, Oxford Bioscience Partners, HIV and SBDD: Let's think radically about resistance

12:30              End of Meeting


Poster Sessions-The 25th Annual Meeting of the Groups Studying the Structures of AIDS-Related Systems and Their Application to Targeted Drug Design

03/28/2011 - 03/30/2011
Monday poster session
 
M1. Expression and purification of HIV-1 Integrase in complex with LEDGF and Importin for structural studies. Anirban Adhikari, Shenping Wu, Sarah L. Griner, Yifan Cheng & Robert M. Stroud, Department of Biochemistry and Biophysics, University of California, San Francisco
M2. Structure of DCAF1 in Complex with DDB1: Toward Understanding the Structural Basis of Viral Hijacking of CRL4-DCAF1 E3 Ubiquitin Ligase. Jinwoo Ahn*, Shoucheng Du*, Zach Novince*, Ivan Vorontsov*, Xinmin Li*, Thomas Vu*, Caili Hao§, Magda Gierszewska#, Jacek Skowronski§,#, Angela M. Gronenborn*, and Joanne I. Yeh*, *Department of Structural Biology and Pittsburgh Center for HIV Protein Interactions, University of Pittsburgh School of Medicine; §Department of Molecular Biology and Microbiology, Case Western Reserve School of Medicine;#Cold Spring Harbor Laboratory
M3. Structural and Dynamics Studies of HIV-1 Nef Interactions with Src-family Kinases. John J. Alvarado1, Thomas E. Wales2, Purushottam Narute3, Lori Emert-Sedlak3, Haibin Shi1, John R. Engen2, Thomas E. Smithgall3,4, and Joanne I. Yeh1,4,*, 1Department of Structural Biology, 3Department of Microbiology & Molecular Genetics, and 4Pittsburgh Center for HIV-Protein Interactions, University of Pittsburgh School of Medicine; 2Department of Chemistry & Chem. Biol., Northeastern University
M4. Cell-Free HIV-1 Virucidal Action by Modified Peptide Triazole Inhibitors of Env gp120. Arangassery Rosemary Bastian#+, Kantharaju#, Karyn McFadden#, Caitlin Duffy#, Srivats Rajagopal#, Mark R. Contarino# , Elisabeth Papazoglou+ and Irwin Chaiken#*, #Department of Biochemistry and Molecular Biology, Drexel University College of Medicine; +School of Biomedical Engineering and Health Sciences, Drexel University
M5. Discovery of novel inhibitors of HIV-1 reverse transcriptase by fragment screening. Joseph D. Bauman1,2, Disha Patel1,2,3, Chhaya Dharia1,2,Yulia Frenkel1,2, J. Thomas Eck1,2,4, Marc W. Fromer1,2 , Sameer Ahmed1,2, Rajiv Bandwar1,2, William C. Ho1,2, Arthur D. Clark Jr. 1,2, Kalyan Das1,2, and Eddy Arnold1,2,3,4, Center for Advanced Biotechnology and Medicine1, Department of Chemistry and Chemical Biology2, Department of Medicinal Chemistry3, BioMaPS Institute4, Rutgers University
M6. HIVLink2: informatic support for general project investigation. Richard K. Belew, Cognitive Science Department, University of California San Diego
M7. Characterization of mutation and drug treatment patterns within VA, and USAF clinical data. Richard K. Belew1 and David J. Looney2, 1Cognitive Science Department, University of California San Diego; 2VA San Diego Healthcare System
M8. HIV-1 Capsid Protein Exhibits Structural Heterogeneity in Solution at the Dimer Interface of the C-terminal Domain. In-Ja L. Byeon, Jinwoo Ahn, Jinwon Jung, Chang-Hyeock Byeon and Angela M. Gronenborn, Pittsburgh Center for HIV Protein Interactions, Department of Structural Biology, University of Pittsburgh School of Medicine
M9. Progress toward a high-resolution structure of the HIV-1 restriction factor APOBEC3F. Michael A. Carpenter, Takahide Kono, Brett Anderson, John S. Albin, Elena Harjes, Yongjian Lu, Hiroshi Matsuo, Reuben S. Harris, Department of Biochemistry, Molecular Biology, and Biophysics, Institute for Molecular Virology, Center for Genome Engineering, University of Minnesota
M10. Hexagonal assembly of a restricting TRIM5α protein. Viswanathan Chandrasekaranc,1, Barbie K. Ganser-Pornillosa,b,1, Owen Pornillosa,b, Joseph G. Sodroskid, Wesley I. Sundquistc, and Mark Yeagera,b,e, aDepartment of Molecular Physiology and Biological Physics, University of Virginia School of Medicine; bDepartment of Cell Biology, The Scripps Research Institute; eDivision of Cardiovascular Medicine, Department of Medicine, University of Virginia Health System; cDepartment of Biochemistry, University of Utah; dDepartment of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, and Division of AIDS, Harvard Medical School
M11. Accessory Mutations Maintain Stability in Drug Resistant HIV-1 Protease. Max W. Chang and Bruce E. Torbett, Department of Molecular and Experimental Medicine, The Scripps Research Institute
M12. Development of a Bimolecular Fluorescence Complementation System for Analyzing
HIV-1 Env-Gag Interactions In Vivo
Mary Ann Checkley, Benjamin G. Luttge, and Eric O. Freed, Virus-Cell Interaction Section, HIV Drug Resistance Program, NCI-Frederick
M13. Characterization of host elongation factors recruited by Tat/P-TEFb to enhance viral transcription. Seemay Chou1, Katherine Bao1, Avi Samelson1, Heather Upton1, Anna Nowak1, Ursula Schulze-Gahmen1, Nanhai He1, Nevan Krogan2, Qiang Zhou1, Tom Alber1, 1UC Berkeley, QB3 Institute, HARC Center; 2UCSF, HARC Center
M14. Characterization of Active Site and Allosteric Inhibitors of Human Immunodeficiency Virus Reverse Transcriptase-Associated Ribonuclease H. Suhman Chung1, Jian-Kang Jiang2, Daniel Himmel3, Joseph D. Bauman3, Krzysztof Wojak3, Jason W. Rausch1, Jennifer A. Wilson4, Stephen H. Hughes1, John A. Beutler4, Craig J. Thomas2, Eddy Arnold3 and Stuart F.J. Le Grice1, 1HIV Drug Resistance Program, National Cancer Institute-Frederick; 2NIH Chemical Genomics Center, Rockville; 3CABM, Rutgers University; 4Molecular Discovery Program, National Cancer Institute-Frederick
M15. MiST: Biological relevance of bait-prey pairs identified by affinity purification and mass spectrometry. Peter Cimermancic, Stefanie Jäger, Andrej Sali, Nevan Krogan, California Institute for Quantitative Biosciences (QB3), University of California, San Francisco
M16. Many are called but few are chosen: 25 years of crystallizing HIV-1 reverse transcriptase. Arthur D. Clark, Jr.a, Kalyan Dasa, Joseph Baumana, Chhaya Dhariaa, Rajiv Bandwara, Daniel Himmela, Disha Patela, Sergio Martineza, Steve Tuskea, William Hoa, Paul Boyerb, Patrick K. Clarkb, Aaron Shatkina, Stephen H. Hughesb, Eddy Arnolda, aCenter for Advanced Biotechnology and Medicine (CABM), and Department of Chemistry and Chemical Biology, Rutgers University; bNCI-Frederick Cancer Research and Development Center
M17. Discovering Novel Eukaryotic Substrates of HIV Protease. Starlynn Clarke1, Anthony O’Donoghue1, Stefanie Jäger2,3, Dave Barkan3,4, Alegra Eroy-Reveles1, Sumit Chanda5, Andrej Sali3,4, Alma Burlingame4, Nevan Krogan2,3, Charles Craik1, 1 Department of Pharmaceutical Chemistry, University of California, San Francisco; 2 Department of Cellular and Molecular Pharmacology, University of California, San Francisco;3 California Institute for Quantitative Biomedical Research, QB3, San Francisco; 4 Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco; 5 Sanford-Burnham Medical Research Institute
M18. Role of SP1 Domain in HIV-1 particle assembly: A molecular switch? Siddhartha A.K. Datta1, Lakew G. Temeselew1, Rachael M. Crist1, Ferri Soheilian2,Anne Kamata2, Jane Mirro1, Demetria Harvin1, Kunio Nagashima2, Raul E. Cachau3, and Alan Rein1, HIV Drug Resistance Program, National Cancer Institute-Frederick1; Electron Microscope Laboratory2, and Information Systems Program3, SAIC-Frederick, Inc.
M19. A Novel Mechanism for NNRTI Resistance of HIV-1 Reverse Transcriptase. Daniel J. Deredge, Kathryn J. Howard, Mary D. Barkley and Patrick L. Wintrode, Case Western Reserve University
M20. Electron Cryotomography of ESCRT in Sulfolobus acidocaldarius. Authors: Megan Dobro1, Rachel Samson2, Stephen Bell2, Grant Jensen1, California Institute of Technology1; Oxford University Dunn School of Pathology2
M21. Application of ultrafast shape recognition to comparing small molecule structures and variation in the conformation of the non-nucleoside inhibitor (NNRTI) binding site of HIV-1 reverse transcriptase. J. Thomas Eck1,2, Kalyan Das2,3, Joseph D. Bauman2,3, Disha Patel2,4, Eddy Arnold2,3, 1BioMaPS Institute for Quantitative Biology, Rutgers University; 2Center for Advanced Biotechnology and Medicine, Rutgers University; 3Department of Chemistry and Chemical Biology, Rutgers University; 4Department of Medicinal Chemistry, Rutgers University
M22. Exploring the interaction between DDX1 and HIV export factor Rev. Steven Edgcomb*, John A. Hammond*, Andrew B. Carmel, Jamie R. Williamson, The Scripps Research Institute Department of Molecular Biology
M23. Cell Surface Distribution of HIV Coreceptor CCR5 Sub-populations. Ayanna Flegler1, Reem Berro2, John P. Moore2, Thomas J. Hope1, 1Department of Cellular and Molecular Biology, Northwestern University; 2Department of Microbiology and Immunology, Weill Medical College of Cornell University
M24. Helical peptidomimetics in Inhibition of HIV fusion. Miriam Gochin1,2*,Xiaoqian Yu1, Aaron Phillips1, Landon Whitby4 , Dale Boger4, 1Touro University – California; 2UCSF Department of Pharmaceutical Chemistry; 4Scripps Research Institute
M25. Multiscale Computer Simulation of the HIV-1 Viral Capsid and Immature Virion. John M. A. Grimeand Gregory A. Voth, Department of Chemistry, James Franck Institute, Institute for Biophysical Dynamics; Computation Institute, University of Chicago
M26. Exploring the function and interaction of RNA helicase DDX1with Rev oligomerization one molecule at a time. John A. Hammond*, Rajan Lamichhane*, Rae Robertson, J. C. Van Der Schans, Svitlana Berezhna, Stephen Edgcomb, David P. Millar, The Scripps Research Institute Department of Molecular Biology
M27. Studies of HIV-1 Protein Assemblies by Solid-state MAS NMR Spectroscopy. Yun Han1, 2, Christopher Suiter1, 2, Guangjin Hou1, 2, Jinwoo Ahn2, 3,In-Ja Byeon2, 3, Angela M Gronenborn2, 3 Sherimay Ablan4, Eric Freed4, andTatyana Polenova1, 2, 1 University of Delaware, Dept of Chemistry and Biochemistry; 2,3 Pittsburgh Center for HIV Protein Interactions and Department of Structural Biology, University of Pittsburgh School of Medicine; 4 National Cancer Institute at Frederick, NIH
M28. Tyrosine Dynamics of HIV-1 CA Protein Assemblies by Solid-State Magic Angle Spinning NMR Spectroscopy: Snapshots from Multiple Timescales. Guangjin Hou1, 2, Yun Han1, 2, Christopher Suiter1, 2, In-Ja L. Byeon2, 3, Jinwoo Ahn2, 3, Jason Concel2, 3, Angela M. Gronenborn2, 3, and Tatyana Polenova1, 2, 1 University of Delaware, Dept of Chemistry and Biochemistry; 2 Pittsburgh Center for HIV Protein Interactions, University of Pittsburgh School of Medicine; 3 Department of Structural Biology, University of Pittsburgh School of Medicine
M29. Reverse transcription facilitates HIV-1 uncoating. Amy E. Hulme, Omar Perez, and Thomas J. Hope, Department of Cell and Molecular Biology, Northwestern University
M30. Global Analysis of HIV-Human Protein Complexes. Stefanie Jäger1,2, Peter Cimerman?i?2,3, Natali Gulbahce1,2, Jeff Johnson1,2, Michael Shales1,2, Marie Fahey1,2, Dong Young Kim4, Starlynn Clarke4, Cathal Mahon4, Eunju Kwon4, Kathryn McGovern1,2, Eyal Akiva2,3, Lars Pache5, Ivan D’Orso6, Rebecca LaRue7, Keisuke Shindo7, Jason Fernandes6, John Morris4, Anthony O’Donoghue4, Kathy Li1,4, Hilda Barry1,4, Gerard Cagney8, Sumit Chanda5, Tanja Kortemme2,3, Ryan Hernandez2,3, Reuben Harris2, Charles Craik4, John Gross4, Alma Burlingame4, Alan Frankel6, Andrej Sali2,3, Nevan Krogan1,2, 1 Department of Cellular and Molecular Pharmacology, University of California, San Francisco; 2 California Institute for Quantitative Biomedical Research, QB3;3 Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco; 4 Department of Pharmaceutical Chemistry, University of California, San Francisco;5 Sanford-Burnham Medical Research Institute; 6 Department of Biochemistry and Biophysics, University of California, San Francisco; 7 University of Minnesota; 8 Conway Institute, University College Dublin
M31. Host-Virus Interactions in Rev-mediated RNA trafficking. Bhargavi Jayaraman1, Jason Fernandes3, David Booth4, Stefanie Jaeger2, David Mavor1, Isabel Ribeiro1, Nevan Krogan2, Yifan Cheng1, and Alan Frankel1, HIV Accessory and Regulatory Complex Center, 1Department of Biochemistry and Biophysics, 2Department of Cellular and Molecular Pharmacology, 3Graduate Program in Pharmaceutical Sciences & Pharmacogenomics, 4Graduate Group in Biophysics, University of California, San Francisco
M32. Global Analysis of Host Post-Translational Modifications in HIV -1 Infection. Jeffrey R. Johnson, Stefanie Jäger, Nevan J. Krogan, Department of Cellular and Molecular Pharmacology, University of California, San Francisco
M33. Crystal Structure of the extracellular domain of Tetherin in a novel disulphide linked anti-parallel format. M. Gordon Joyce, Peter D. Sun, Structural Immunology Section, Lab of Immunogenetics, National Institute of Allergy and Infectious Diseases, NIH
M34. Uncovering Lentiviral Interactome Evolution. Joshua Kane, Stefanie Jager, Jeffrey Johnson, Rebecca LaRue, Ryan Hernandez, Reuben Harris, Nevan Krogan, University of California San Francisco
M35. Designing Promiscuous Inhibitors: Lessons Learned from HIV-1 Protease Inhibition. Yang Shen¹, Mala L. Radhakrishnan², Bruce Tidor¹, ¹ Department of Biological Engineering, and Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology; ² Department of Chemistry, Wellesley College
M36. HIV-1 gp120 Determinants for Peptide Triazole Inhibitor Binding and Dual Receptor Site Antagonism. Ferit Tuzer1, Kantharaju1, Navid Madani2, Andrew Holmes1, Karyn McFadden1, Judith LaLonde3, Joseph Sodroski2, Irwin Chaiken1, 1Department of Biochemistry and Molecular Biology, Drexel University College of Medicine; 2Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School; 3Department of Chemistry, Bryn Mawr College
 

 
Tuesday poster session
 
T1. Biochemical and Structural Analyses of the LIP5-CHMP5 Complex. Ângela Katsuyama, Jack Skalicky, William Stubblefield, Jun Arii, Leremy Colf, Nathan Uter, Diane Ward, Rebecca Rich, David Myszka, Wesley Sundquist, University of Utah, Department of Biochemistry
T2. Cellular factors that modulate assembly and activity of the HIV Vif hijacked Cul5 E3 ubiquitin ligase. Dong Young Kim1, David Stanley1, Eunju Kwon1, Linda Yen1, Stefanie Jaeger2, Koen Bartholomeeusen3, Keisuke Shindo4, Rebecca S. LaRue4, Ming Li4, Cathal Mahon1, Natali Gulbache2, Jeff Johnson2, Kathryn McGovern2, Charles Craik1, Al Burlingame1, Matija Peterlin3, Reuben S. Harris4, Nevan Krogan2 and John Gross1, University of California, San Francisco 1Department of Pharmaceutical Chemistry, 2Cellular and Molecular Pharmacology, and 3Department of Medicine; 4University of Minnesota Department of Biochemistry, Molecular Biology and Biophysics
T3. APOBEC2 might not be a good model for APOBEC3G. Troy C. Krzysiak, Angela Gronenborn, University of Pittsburgh Department of Structural Biology
T4. Characterizing the Role of HIV-1 p6-Alix Binding in HIV-1 Replication. Lillian S. Kuo, Ken Fujii, and Eric O. Freed, Virus–Cell Interaction Section, HIV Drug Resistance Program, National Cancer Institute at Frederick
T5. In Vitro Selection of Resistance Mutations to Novel HIV-1 Protease Inhibitors Using a Mixture of HIV-1 Variants Bearing Resistance Mutations to Conventional Protease Inhibitors. Sook-Kyung Lee1, Celia Schiffer2, and Ronald Swanstrom1, 1Department of Biochemistry and Biophysics, and the UNC Center for AIDS Research, University of North Carolina at Chapel Hill; 2Department of Biochemistry and Molecular Pharmacology,University of Massachusetts, Worcester
T6. Interogating the APOBEC3G DNA Cytosine Deamination Mechanism with Chemical Inhibitors. Ming Li and Reuben S. Harris, Department of Biochemistry, Molecular Biology and Biophysics, Institute for Molecular Virology, Center for Genome Engineering, University of Minnesota
T7. Functional Characterization of Vpr-Host Protein-Protein Interactions. Cathal Mahon1,2, Stefanie Jäger1, Vicente Planelles3, Jinwoo Ahn4, Zandrea Ambrose5, Angela Gronenborn4, Alma Burlingame2, Charles Craik2 and Nevan Krogan1, 1Department of Cell & Molecular Pharmacology, University of California, San Francisco; 2Department of Pharmaceutical Chemistry, University of California, San Francisco; 3Department of Pathology, University of Utah School of Medicine; 4Departments of Structural Biology and Microbiology and Molecular Genetics, Pittsburgh Center for HIV Protein Interactions, University of Pittsburgh School of Medicine and Cancer Institute; 5Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine
T8. HNG-156 is a Potential Microbicide Candidate with Broad Anti-Viral Activity Alone or in Combination with Other Inhibitors. Karyn McFadden1, Patricia Fletcher2, Fiorella Rossi1, Kantharaju1, Muddagowda Umashankara1, Srivats Rajagopol, Vanessa Pirrone,1 Hosahudya Gopi3, Fred Krebs1, Julio Martin-Garcia1 Robin Shattock2and Irwin Chaiken1, 1Drexel University College of Medicine; 2St. Georges University London; 3Indian Institute of Science Education and Research
T9. Allostery and HIV-Host Interactions. Christopher McClendon, Salma Rafi, and Matthew P. Jacobson, HARC Center, UCSF
T10. CA-NC Cleavage Is Required for Formation of the Mature Capsid Interfaces. Xin Meng1, Gongpu Zhao1, Danxia Ke1, Ernest Yufenyuy2, Jinwoo Ahn1, Angela M. Gronenborn1, Christopher Aiken2, Peijun Zhang1, 1Department of Structural Biology, University of Pittsburgh School of Medicine; 2Department of Microbiology and immunology, Vanderbilt University School of Medicine
T11. Characterization of the host cell interactome of HIV-1 Rev by proteomics reveals novel RNA helicases involved in HIV replication. Souad Naji1*, Geza Ambrus-Aikelin1*, Jason Reyes1, Jeff Johnson1, Peter Cimerancic2#, Saumya Jain1*, Eric Singer1*, Anna Figueiredo3*, Tom Hope3*, Nevan Krogan2# John Yates1, Andrew Saphire1, and Larry Gerace1*, 1Depts. of Cell and Molecular Biology, The Scripps Research Institute; 2Dept. of Cellular and Molecular Pharmacology, University of California, San Francisco; 3Dept. of Cell and Molecular Biology, Northwestern University; *CHEETAH (Center for the Structural Biology of Cellular Host Elements in Egress, Trafficking and Assembly of HIV); #HARC (HIV/AIDS Resource Center)
T12. Correlative 3D imaging of whole Mammalian Cells with Light Microscopy and Ion Abrasion–Scanning Electron Microscopy. Kedar Narayan#1, Gavin E. Murphy#1, Bradley C. Lowekamp2, Lisa M. Hartnell1, Jing Fu1, Sriram Subramaniam1, 1Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH; 2Office of High Performance Computing and Communications, National Library of Medicine, NIH
T13. Structure-Based Design and Structure-Activity Relationship Studies of HIV-1 Protease Inhibitors. Maloy Kumar Parai, David J. Huggins,§ Hong Cao, Madhavi N. L. Nalam, Celia A. Schiffer,Bruce Tidor,§ and Tariq M. Rana†‡, Program for RNA Biology, Sanford-Burnham Medical Research Institute; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School; §Department of Biological Engineering and Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology
T14. Contextual Determinants May Have a Crucial Role in HIV-1 Protease-Mediated Processing of the MA-CA Cleavage Site in Gag. Marc Potempa1, Sook-Kyung Lee2, and Ronald Swanstrom1,2, 1Department of Microbiology and Immunology, 2Department of Biochemistry and Biophysics, and the UNC Center for AIDS Research, University of North Carolina at Chapel Hill
T15. Advances in biosensor analysis: new tips, chips, arrays, and fragment screening. Rebecca Rich and David Myszka, CHEETAH Protein Interaction Core, University of Utah
T16. Studies of the Antiviral Function of Mouse Apobec3 Using a Fossil Gag MLV Gene. Silvia Sanchez-Martinez1, Amanda Aloia1, Jane Mirro1, Demetria P. Harvin1, Robert J. Gorelick2, Patric Jern3, John M. Coffin3 and Alan Rein1, 1HIV Drug Resistance Program and 2AIDS & Cancer Virus Program, SAIC-Frederick, Inc., National Cancer Institute-Frederick; 3Department of Molecular Biology and Microbiology, Tufts University School of Medicine
T17. Thermodynamic Signatures of Region III Analogs of JRC-II-191 Reveal Functional Differences when Binding to the gp120 Cavity Vestibule. Arne Schöna, Navid Madanib, Amy M. Princiottob, Mark A. Elbanc, Joel R. Courterc, Akihiro Sugawarac, Takahiro Soetac, David M. Jonesc, Alexander W. Sunc, Amos B. Smith, IIIc, Joseph Sodroskib, Judith M. LaLonded, Ernesto Freirea, aDepartment of Biology, The Johns Hopkins University; bDepartment of Cancer Immunology and AIDS, Dana-Farber Cancer Institute; cDepartment of Chemistry, University of Pennsylvania, Philadelphia, PA 19104; dDepartment of Chemistry, Bryn Mawr College
T18. Structural and functional studies of Tat-P-TEFb-supercomplexes. Ursula Schulze-Gahmen, Seemay Chou, Katherine Bao and Tom Alber, Department of Molecular and Cell Biology, HARC Center, University of California, Berkeley
T19. Nanoscale dynamics of ABOBEC3G in complexes with DNA. Luda S. Shlyakhtenko1, Alexander Y. Lushnikov1, Atsushi Miyagi1, Ming Li2, Reuben S. Harris2 and Yuri L. Lyubchenko1,*, 1Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center; 2Department of Biochemistry, Molecular Biology, and Biophysics, Institute for Molecular Virology, Center for Genome Engineering, Masonic Cancer Center, University of Minnesota
T20. Efficient Computation of Configurational Binding Entropy and Free Energy Changes of HIV-1 Protease Inhibitors by Ensemble Enumeration. Nathaniel W. Silver1   and Bruce Tidor2,3, 1Department of Chemistry, 2Department of Biological Engineering, 3Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology
T21. A synthetic transmembrane domain peptide mimic may inhibit HIV-1 Vpu from antagonizing the innate restriction factor BST-2 by increasing cell surface BST-2 and saturating lipid-embedded helix-helix interactions. Mark Skasko1,§, Yan Wang2,§, Ye Tian2, Andrey Tokarev1, Jason Munguia1, Autumn Ruiz4, Edward Stephens5, Mauricio Montal3, Christian F.W. Becker7, Stanley Opella2,*, and John Guatelli1,6,*, 1Departments of Medicine, 2Chemistry and Biochemistry and 3Section of Neurobiology, University of California, San Diego; 4Department of Anatomy and Cell Biology and 5Department of Microbiology, Molecular Genetics, and Immunology, University of Kansas Medical Center; 6San Diego Veterans Affairs Healthcare System; 7Department of Chemistry, Technische Universität München
T22. Identification of Host Cell Proteins interacting HIV-1 Capsid Core. Humeyra Taskent, Bridget Dixon, Jennifer Miller, Sabrina Lusvarghi, Jason W. Rausch, Vineet KewalRamani and Stuart F. J. Le Grice, HIV Drug Resistance Program, National Cancer Institute, Frederick
T23. Extended model for the HIV-1 human protein interactome. Oznur Tastan1, Stefanie Jäger2, Nevan Krogan2 and Judith Klein-Seetharaman1,3, 1Language Technologies Institute, School of Computer Science, Carnegie Mellon University; 2Department of Cellular and Molecular Pharmacology, University of California,San Francisco; 3Department of Structural Biology, School of Medicine, University of Pittsburgh
T24. Biological Properties of the HIV-1 Matrix Mutant 29KE/31KE. Philip R. Tedbury, Anjali Joshi and Eric O. Freed, Virus-Cell Interaction Section, HIV Drug Resistance Program, NCI-Frederick
T25. Progress Toward an Allosteric Inhibitor of HIV Protease. Theresa Tiefenbrunn1, Stefano Forli1, Alexander Kislukhin2, Alex L. Perryman1, Max Chang3, Sebastian Breuer3, Bruce E. Torbett3, M.G. Finn2, Arthur J. Olson1, John E. Elder1, and C. David Stout1, 1Department of Molecular Biology, 2Department of Chemistry, 3Department of Molecular and Experimental Medicine, The Scripps Research Institute
T26. HIV fusion peptide penetrates, disorders and softens T-cell membrane mimics. Stephanie Tristram-Naglea*, Rob Chana, Edgar Kooijmanb, Pradeep Uppamoochikkala, Wei Qiangc, David P. Welikyc and John F. Naglea,d, aBiological Physics Group, Department of Physics, Carnegie Mellon University; bDepartment of Biological Sciences, Kent State University; cDepartment of Chemistry, Michigan State University; dDepartment of Biological Sciences, Carnegie Mellon University
T27. Structural Studies with Unconventional DNA Chain Terminators. Steve Tuske1, Arthur D. Clark1, Kalyan Das1, Barry Johnson1, B. Christie Vu2, Stephen H. Hughes2, and Eddy Arnold1, 1Center for Advanced Biotechnology and Medicine, Department of Chemistry and Biology, Rutgers University; 2HIV Drug Resistance Program, National Cancer Institute–Frederick
T28. A Tale of Two HIV-1 Maturation Inhibitors – Bevirimat (BVM) and PF-46396: Insights into Gag Assembly and Virion Maturation. Kayoko Waki1, Scott Butler2, and Eric O. Freed1, 1Virus-Cell Interaction Section, HIV Drug Resistance Program, NCI-Frederick; 2 Pfizer Global Research and Development, Sandwich, Kent, UK
T29. Molecular Architectures of Trimeric SIV and HIV-1 Envelope Glycoproteins on Intact Viruses: Strain-Dependent Variation in Quaternary Structure. Tommi A. White1, Alberto Bartesaghi1, Mario J. Borgnia1, Joel R. Meyerson1, M. Jason V. de la Cruz1, Julian W. Bess2, Rachna Nandwani1, James A. Hoxie3, Jeffrey D. Lifson2, Jacqueline L. S. Milne1, Sriram Subramaniam1*, 1Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda; 2AIDS and Cancer Virus Program, SAIC-Frederick, Inc., National Cancer Institute-Frederick; 3Department of Medicine, University of Pennsylvania
T30. A Method of Fluorescently Staining Intracellular HIV-1 RNA to Discover Host Cell Factors that Interact with Capsid Uncoating and Reverse Transcription. Hongzhan Xu1, Tamera Franks1, Gregory Gibson2, Nicolas Sluis-Cremer1, Simon Watkins2, and Zandrea Ambrose1, 1Division of Infectious Diseases, Department of Medicine and 2Department of Cell Biology and Molecular Physiology, University of Pittsburgh School of Medicine
T31. Development of HIV-1 Capsid Assembly Inhibitors: A Structure-Based Conformational-Trapping Approach. Naveena Yanamala1, Haibin Shi1, Irtisha Singh1, Shoucheng Du1, JinwooAhn1, Alexander Dömling2, Chang-Hyeon Byeon1, Jing Zhou3, Samantha Minten3, Christopher Aiken3, In-Ja L. Byeon1, JoanneYeh1,*, and Judith Klein-Seetharaman1,*, 1Department of Structural Biology and 2Department of Pharmaceutical Sciences, University of Pittsburgh School of Medicine; 3Department of Microbiology & Immunology, Vanderbilt University School of Medicine
T32. Mutations at the NTD-CTD Intersubunit Interface Perturb HIV-1 Capsid Stability and Infectivity. Ernest L. Yufenyuy and Christopher Aiken, Department of Microbiology and Immunology, Vanderbilt University School of Medicine
T33. ALIX Undergoes a Functionally Important Conformational Change. Qianting Zhai1, Michael B. Landesman1, Hyo?Young Chung1, Robert D. Fisher1, John McCullough1, David G. Myszka2, Cy M. Jeffries3, Adam Dierkers3, Jill Trewhella3, Wesley I. Sundquist1, Christopher P. Hill1, 1Department of Biochemistry and 2Center for Biomolecular Interactions Analysis, University of Utah School of Medicine; 3School of Molecular and Microbial Biosciences, University of Sydney
T34. Structural and Functional Studies on the Extracellular Domain of BST2/Tetherin in Reduced and Oxidized Conditions. Qianting Zhai1, Heidi L. Schubert1, Virginie Sandrin1, Debra M. Eckert1, Mitla Garcia-Maya2, Louise Saul2, Wesley I. Sundquist1, Roberto A. Steiner2, Christopher P. Hill1, 1Department of Biochemistry, University of Utah School of Medicine; 2Randall Division of Cell and Molecular Biophysics, King's College London
T35. Subnanometer resolution structure of HIV-1 capsid assembly. Gongpu Zhao1, Xin Meng1, Ruifeng Yang2, Christopher Aiken2, Angela M. Gronenborn1 and Peijun Zhang1*, 1Department of Structural Biology, University of Pittsburgh School of Medicine; 2Department of Microbiology and Immunology, Vanderbilt University School of Medicine
T36. Development of a Novel Antiviral Therapy for Feline Leukemia Virus Infection. Willie M. Greggs III1,3, Christine L. Clouser1,2, Steven E. Patterson1,4, Louis M. Mansky1,2,3,4,5, 1Institute for Molecular Virology, 2Department of Diagnostic and Biological Sciences. School of Dentistry, 3Comparative Molecular Biosciences Program. College of Veterinary Medicine, 4Center for Drug Design, Academic Health Center, 5Department of Microbiology. Medical School, University of Minnesota
T37. Inhibiting the APOBEC3G catalytic domain: Insights from crystallography and in-silico modeling.  Shivender M.D. Shandilya(1), Ming Li(2), Reuben S. Harris(2) and Celia A. Schiffer(1), (1): Biochemistry & Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA; (2): Department of Biochemistry, Molecular Biology and Biophysics, Institute for Molecular Virology, Center for Genome Engineering, University of Minnesota
Version: 2.1.0