Structural Biology Related to HIV/AIDS - 2016

06/23/2016 - 06/24/2016 Agenda  

Agenda - Structural Biology Related to HIV/AIDS – 2016



8:00 – 8:15      Carl Dieffenbach (National Institute of Allergy and Infectious Diseases)

                       Opening Remarks


Session I:  Reports from Specialized Centers (P50); Session Chair: Wes Sundquist


8:15 – 9:15      The Center for HIV RNA Studies (CRNA)


                       Michael Summers (University of Maryland Baltimore County)

                       Influence of 5’-start Site Heterogeneity and Capping on HIV-1 RNA Structure and Fate


                       Victoria D'Souza (Harvard University)

                       Understanding Translational Regulation in HIV-1


                       Owen Pornillos (University of Virginia)

                       Crystal Structure of the CA-SP1 Assembly and Maturation Switch


                       Sanford Simon (Rockefeller University)

                       Steps in the Assembly of HIV-1


9:15 – 10:15    The Center for HIV Accessory and Regulatory Complexes (HARC)


                       Nevan Krogan (University of California San Francisco)

                       The HARC Center: Progress and Overview


                       Alex Marson (University of California San Francisco)

                       Genome Engineering Primary Human T Cells to Test Function of Host Factors in HIV Pathogenesis


                       Alan Frankel (University of California San Francisco)

                       Functional Segregation of Overlapping Genes in HIV


                       Charles Craik (University of California San Francisco)

                       Identifying Recombinant Antibodies to Challenging HIV Related Targets


10:15 – 10:45  BREAK


Session II:  Reports from Specialized Centers (P50) continued; Session Chair:  Irwin Chaiken


10:45 – 11:45  The HIV Interaction and Viral Evolution Center (HIVE)


                       Arthur Olson (The Scripps Research Institute)

                       HIVE Center: HIV Interactions and Viral Evolution of Drug Resistance


                       Mamuka Kvaratskhelia (Ohio State University)

                       HIV-1 Integrase Binds the Viral RNA Genome and Is Essential During Virion Morphogenesis


                       Eddie Arnold (Rutgers University)

                       A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain


                       Crystal Structure of Prototype Foamy Virus PR-RT Polyprotein Shows Unique Architecture Among Retroviruses: Implications for Function


                       Stefan Sarafianos (University of Missouri, Columbia)

                       Visualization of Viral RNA and DNA Dynamics During HIV infection


11:45 – 1:00    LUNCH


1:00 – 3:00      POSTER SESSION


Session III:  Reports from Specialized Centers (P50) continued; Session Chair:  Alan Frankel


3:00 – 4:00      The Pittsburgh Center for HIV Protein Interactions (PCHPI)


                       Tatyana Polenova (University of Delaware)

                       Dynamic Regulation of HIV-1 Capsid Assembly, Maturation, and Interactions with Host Factors by Integrated MAS NMR and MD Simulations


                       Jacek Skowronski (Case Western Reserve University)

                       HIV-1 and HIV-2 Exhibit Divergent Interactions with DNA Repair Enzymes


                       Guillermo Calero (University of Pittsburgh)

                       To Repair or Not Repair: The X-Ray Structure of the DDB1-DCAF1-Vpr-UNG2 Complex


4:00 – 5:00      The Center for the Structural Biology of Cellular Host Elements in Egress, Trafficking, and Assembly of HIV (CHEETAH)


                       Wes Sundquist (University of Utah)

                       Introduction to the Center


                       Michael Kay (University of Utah)

                       D-Peptide Fusion Inhibitor Protects Against High-Dose SHIV Challenge


                       Tom Hope (Northwestern University)

                       Visualizing HIV Uncoating in Living Cells


                       Barbie Ganser-Pornillos (University of Virginia)

                       Structural Studies of TRIM5α


5:00                ADJOURN FOR DAY






Session IV: Invited Speakers, Session Chair: Elizabeth Church


8:00 – 8:30      Debora Marks (Harvard Medical School)

                       Structure and Function of RNA and Proteins from Natural Sequence Variation


8:30 – 9:00      Kushol Gupta (University of Pennsylvannia)

                       Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase


Session V: Selected Posters, Session Chair: Alice Telesnitsky


9:00 – 9:30      Lars-Anders Carlson (University of California Berkeley)

                       Biochemical Reconstitution of Selective HIV-1 Genome Packaging


9:30 – 10:00    Pamela Bjorkman (California Institute of Technology)

                       Structure of a Natively-Glycosylated HIV-1 Env Reveals a New Mode for VH1-2 Antibody Recognition of the CD4 Binding Site Relevant to Vaccine Design


10:00 – 10:30  BREAK


Session V: Targeting Envelope, Session Chair: Arthur Olson


10:30 – 11:15  P01: Structure-Based Antagonism of HIV-1 Envelope Function in Cell Entry


                       Irwin Chaiken (Drexel University)

                       Overview of the Program and Recent Progress


                       Ernesto Freire (Johns Hopkins University)

                       Conformational Transformations Triggered by Different Inhibitor Classes


                       Alon Herschhorn (Dana-Farber Cancer Institute)

                       An Intermediate State of the HIV-1 Envelope Glycoproteins on the Entry Pathway


Session VI: Protease Drug Resistance, Angela Gronenborn:


11:15 – 12:00  P01: The Interdependency of Drug Resistance Evolution and Drug Design: HIV-1 Protease


                       Celia Schiffer (UMass Medical School)

                       Project Overview


                       Rieko Ishima (University of Pittsburgh)

                       Establish a Strategy to Elucidate Molecular Mechanisms Leading to Drug Resistance


                       Daniel Bolon (UMass Medical School)

                       Systematic Exploration of Mutational Pathways to Drug Resistance in HIV Protease


12:00 – 1:00    LUNCH

                       (SAB Lunch, Room B; Please bring your lunch.)


1:00 – 3:00      POSTER SESSION

(1:00 – 3:00     NIGMS Centers Scientific Review Board; Room B)


Session VIII: Selected Posters Cont., Session Chair: Celia Schiffer


3:00 – 3:30      Ursula Schulze-Gahmen (University of California Berkeley)

                       Insights into HIV-1 Proviral Transcription from an Integrative Structure of the Tat:AFF4:P-TEFb:TAR Complex


3:30 – 4:00      Guney Boso (Sanford Burnham Institute)

                       Arrayed Analysis of Immune Evasion: High Content Imaging Screen Reveals Novel Targets of HIV-1 Vpu


4:00 – 4:30      Gregory Melikyan (Emory University)

                       Real-Time Imaging of Single HIV-1 Uncoating in Cells


4:30 – 5:00      Markus Thali (University of Vermont)

                       More is Less: Enhancing Virus-Induced Membrane Fusion to Inhibit Viral Spread




5:00                ADJOURN MEETING






Mark Your Calendars!


Structural Biology Related to HIV/AIDS – 2017

Thursday June 29 – Friday June 30, 2017

Natcher Conference Center, Bethesda, Maryland

Version: 2.0.0