Agenda

Structural Biology Related to HIV/AIDS - 2016

06/23/2016 - 06/24/2016 Agenda  

Agenda - Structural Biology Related to HIV/AIDS – 2016

 

DAY 1

8:00 – 8:15      Carl Dieffenbach (National Institute of Allergy and Infectious Diseases)

                       Opening Remarks

 

Session I:  Reports from Specialized Centers (P50); Session Chair: Wes Sundquist

 

8:15 – 9:15      The Center for HIV RNA Studies (CRNA)

 

                       Michael Summers (University of Maryland Baltimore County)

                       Influence of 5’-start Site Heterogeneity and Capping on HIV-1 RNA Structure and Fate

 

                       Victoria D'Souza (Harvard University)

                       Understanding Translational Regulation in HIV-1

 

                       Owen Pornillos (University of Virginia)

                       Crystal Structure of the CA-SP1 Assembly and Maturation Switch

 

                       Sanford Simon (Rockefeller University)

                       Steps in the Assembly of HIV-1

 

9:15 – 10:15    The Center for HIV Accessory and Regulatory Complexes (HARC)

 

                       Nevan Krogan (University of California San Francisco)

                       The HARC Center: Progress and Overview

 

                       Alex Marson (University of California San Francisco)

                       Genome Engineering Primary Human T Cells to Test Function of Host Factors in HIV Pathogenesis

 

                       Alan Frankel (University of California San Francisco)

                       Functional Segregation of Overlapping Genes in HIV

 

                       Charles Craik (University of California San Francisco)

                       Identifying Recombinant Antibodies to Challenging HIV Related Targets

 

10:15 – 10:45  BREAK

 

Session II:  Reports from Specialized Centers (P50) continued; Session Chair:  Irwin Chaiken

 

10:45 – 11:45  The HIV Interaction and Viral Evolution Center (HIVE)

 

                       Arthur Olson (The Scripps Research Institute)

                       HIVE Center: HIV Interactions and Viral Evolution of Drug Resistance

 

                       Mamuka Kvaratskhelia (Ohio State University)

                       HIV-1 Integrase Binds the Viral RNA Genome and Is Essential During Virion Morphogenesis

 

                       Eddie Arnold (Rutgers University)

                       A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain

 

                       Crystal Structure of Prototype Foamy Virus PR-RT Polyprotein Shows Unique Architecture Among Retroviruses: Implications for Function

 

                       Stefan Sarafianos (University of Missouri, Columbia)

                       Visualization of Viral RNA and DNA Dynamics During HIV infection

 

11:45 – 1:00    LUNCH

 

1:00 – 3:00      POSTER SESSION

 

Session III:  Reports from Specialized Centers (P50) continued; Session Chair:  Alan Frankel

 

3:00 – 4:00      The Pittsburgh Center for HIV Protein Interactions (PCHPI)

 

                       Tatyana Polenova (University of Delaware)

                       Dynamic Regulation of HIV-1 Capsid Assembly, Maturation, and Interactions with Host Factors by Integrated MAS NMR and MD Simulations

 

                       Jacek Skowronski (Case Western Reserve University)

                       HIV-1 and HIV-2 Exhibit Divergent Interactions with DNA Repair Enzymes

 

                       Guillermo Calero (University of Pittsburgh)

                       To Repair or Not Repair: The X-Ray Structure of the DDB1-DCAF1-Vpr-UNG2 Complex

 

4:00 – 5:00      The Center for the Structural Biology of Cellular Host Elements in Egress, Trafficking, and Assembly of HIV (CHEETAH)

 

                       Wes Sundquist (University of Utah)

                       Introduction to the Center

 

                       Michael Kay (University of Utah)

                       D-Peptide Fusion Inhibitor Protects Against High-Dose SHIV Challenge

 

                       Tom Hope (Northwestern University)

                       Visualizing HIV Uncoating in Living Cells

 

                       Barbie Ganser-Pornillos (University of Virginia)

                       Structural Studies of TRIM5α

 

5:00                ADJOURN FOR DAY

 

 

DAY TWO

 

 

Session IV: Invited Speakers, Session Chair: Elizabeth Church

 

8:00 – 8:30      Debora Marks (Harvard Medical School)

                       Structure and Function of RNA and Proteins from Natural Sequence Variation

 

8:30 – 9:00      Kushol Gupta (University of Pennsylvannia)

                       Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase

 

Session V: Selected Posters, Session Chair: Alice Telesnitsky

 

9:00 – 9:30      Lars-Anders Carlson (University of California Berkeley)

                       Biochemical Reconstitution of Selective HIV-1 Genome Packaging

 

9:30 – 10:00    Pamela Bjorkman (California Institute of Technology)

                       Structure of a Natively-Glycosylated HIV-1 Env Reveals a New Mode for VH1-2 Antibody Recognition of the CD4 Binding Site Relevant to Vaccine Design

 

10:00 – 10:30  BREAK

 

Session V: Targeting Envelope, Session Chair: Arthur Olson

 

10:30 – 11:15  P01: Structure-Based Antagonism of HIV-1 Envelope Function in Cell Entry

 

                       Irwin Chaiken (Drexel University)

                       Overview of the Program and Recent Progress

 

                       Ernesto Freire (Johns Hopkins University)

                       Conformational Transformations Triggered by Different Inhibitor Classes

 

                       Alon Herschhorn (Dana-Farber Cancer Institute)

                       An Intermediate State of the HIV-1 Envelope Glycoproteins on the Entry Pathway

 

Session VI: Protease Drug Resistance, Angela Gronenborn:

 

11:15 – 12:00  P01: The Interdependency of Drug Resistance Evolution and Drug Design: HIV-1 Protease

 

                       Celia Schiffer (UMass Medical School)

                       Project Overview

 

                       Rieko Ishima (University of Pittsburgh)

                       Establish a Strategy to Elucidate Molecular Mechanisms Leading to Drug Resistance

 

                       Daniel Bolon (UMass Medical School)

                       Systematic Exploration of Mutational Pathways to Drug Resistance in HIV Protease

 

12:00 – 1:00    LUNCH

                       (SAB Lunch, Room B; Please bring your lunch.)

 

1:00 – 3:00      POSTER SESSION

(1:00 – 3:00     NIGMS Centers Scientific Review Board; Room B)

 

Session VIII: Selected Posters Cont., Session Chair: Celia Schiffer

 

3:00 – 3:30      Ursula Schulze-Gahmen (University of California Berkeley)

                       Insights into HIV-1 Proviral Transcription from an Integrative Structure of the Tat:AFF4:P-TEFb:TAR Complex

 

3:30 – 4:00      Guney Boso (Sanford Burnham Institute)

                       Arrayed Analysis of Immune Evasion: High Content Imaging Screen Reveals Novel Targets of HIV-1 Vpu

 

4:00 – 4:30      Gregory Melikyan (Emory University)

                       Real-Time Imaging of Single HIV-1 Uncoating in Cells

 

4:30 – 5:00      Markus Thali (University of Vermont)

                       More is Less: Enhancing Virus-Induced Membrane Fusion to Inhibit Viral Spread

 

 

 

5:00                ADJOURN MEETING

 

 

 

 

 

Mark Your Calendars!

 

Structural Biology Related to HIV/AIDS – 2017

Thursday June 29 – Friday June 30, 2017

Natcher Conference Center, Bethesda, Maryland

Version: 2.0.0