Structural Biology Related to HIV/AIDS - 2017

06/29/2017 - 06/30/2017

Agenda - Structural Biology Related to HIV/AIDS – 2017




8:00 – 8:15       Maureen Goodenow (NIH Office of AIDS Research)

                           Opening Remarks


Session I:  Reports from Specialized Centers (P50); Session Chair: Irwin Chaiken


8:15 – 9:15       The Pittsburgh Center for HIV Protein Interactions (PCHPI)


                           Zandrea Ambrose (University of Pittsburgh)

                           Strangers on a Train: Imaging of HIV-1 and Host Proteins on Microtubules


                           Peijun Zhang (University of Pittsburgh)

                           Cryo-EM Structure of MxB Assembly Reveals a Novel Oligomerization Interface Critical for HIV Restriction


                           Peter Cherepanov (The Francis Crick Institute)

                           Cryo-EM structures of the Maedi-Visna Virus Intasome


                           Chris Aiken (Vanderbilt University)

                           Inhibition of HIV-1 Maturation via Small Molecule Targeting of the Amino-Terminal Domain in the Viral Capsid Protein


9:15 – 10:15    The Center for HIV Accessory and Regulatory Complexes (HARC)


                           Nevan Krogan (University of California San Francisco)

                           The HARC Center: Overview and Progress


                           John Gross (University of California San Francisco)

                           Structure and Mechanism of Fab-Based Inhibitors of the HIV-1 Vif E3 Ubiquitin Ligase


                           James Hurley (University of California Berkeley)

                           HIV-1 Nef as a Cargo-Selective Allosteric Switch in Hijacking Clathrin Coated Vesicles


10:15 – 10:45  BREAK


Session II:  Reports from Specialized Centers (P50) continued; Session Chair: Celia Schiffer


10:45 – 11:45  The Center for HIV RNA Studies (CRNA)


                           Alice Telesnitsky (University of Michigan)

                           Introduction to the Center for HIV-1 RNA Studies


                           Amanda Hargrove (Duke University)

                           The Distinguishing Properties of Bioactive RNA-Targeted Small Molecules


                           Janet Smith (University of Michigan)

                           APOBEC3H Catalytic Activity and RNA Binding



                           Paul Bieniasz (Institution)

                           Evasion of Intrinsic Host Defenses Drives HIV-1 Nucleotide Composition


11:45 – 1:00    LUNCH


1:00 – 3:00       POSTER SESSION


Session III:  Reports from Specialized Centers (P50) continued; Session Chair: Nevan Krogan


3:00 – 4:00       The Center for the Structural Biology of Cellular Host Elements in Egress, Trafficking, and Assembly of HIV (CHEETAH)


                           Wesley Sundquist (University of Utah)

                           Introduction to the Center


                           Adam Frost (University of California San Francisco)

                           Structures and Functions of ESCRT-III Filaments


                           Chris Hill (University of Utah)

                           Structure and Mechanism of the Vps4 ATPase


                           Nels Elde (University of Utah)

                           Evolution of Antiviral Retrogenes


4:00 – 5:00       The HIV Interaction and Viral Evolution Center (HIVE)


                           Bruce Torbett (The Scripps Research Institute)

                           The HIV Interaction and Viral Evolution (HIVE) Center: Overview and Progress


                           Mamuka Kvaratskhelia (Ohio State University)

                           Critical Structural Determinants for ALLINI-Induced Aggregation of HIV-1 Integrase


                           Ronald Levy (Temple University)

                           Exploring Fitness and Energy Landscapes of HIV Proteins


                           Stefan Sarafianos (University of Missouri)

                           The HIV Interaction and Viral Evolution (HIVE) Center: Future Directions


5:00                   ADJOURN FOR DAY





Session IV: Envelope Function and Targeting, Session Chair: Wes Sundquist


8:00 – 8:30       Michael Root (NIAID Invited Speaker; Thomas Jefferson University)

                           Receptor Utilization by HIV-1 Env During Viral Entry


8:30 – 9:15       P01: Structure-Based Antagonism of HIV-1 Envelope Function in Cell Entry


                           Irwin Chaiken (Drexel University)

                           Targeting HIV-1 Env for Inhibition and Inactivation


                           Walther Mothes (Yale University)

                           Associating HIV-1 Env Trimer Structures with Functional Env Conformational States by smFRET Analysis


                           Amos B. Smith III (University of Pennsylvania)

                           Design, Synthesis and Biological Evaluation of Small-Molecule Inhibitors of HIV-1 Entry: A Potential Long-Term Strategy for Curbing the AIDS Epidemic


Session V: Gag Assembly and Targeting, Session Chair: Alice Telesnitsky


9:15 – 9:45       David Millar (Selected Poster Talk; The Scripps Research Institute)

                           Single-Molecule Studies of HIV-1 Gag Assembly


9:45 – 10:15    Eric Hu (NIAID Invited Speaker; Gilead Sciences)

                           Disrupting HIV Capsid Assembly by Small Molecule Modulators


10:15 – 10:45  BREAK


Session VI: APOBEC, Session Chair: Bruce Torbett


10:45 – 11:15  Yuri Lyubchenko (Selected Poster Talk; University of Nebraska)

                           Structure and Dynamics of Complexes of APOBEC3G With RNA at Nanoscale


11:15 – 11:45  Reuben Harris (Selected Poster Talk: University of Minnesota)

                           Structural Basis for Targeted DNA Cytosine Deamination and Mutagenesis by APOBEC Enzymes


11:15 – 12:45  LUNCH

                           (SAB Lunch, Room B; Please bring your lunch.)


12:45 – 2:45    POSTER SESSION

(12:45 – 2:45   NIGMS Centers Scientific Review Board; Room B)



Session VII: Protease; Session Chair: Stefan Sarafianos


2:45 – 3:30       P01: The Interdependency of Drug Resistance Evolution and Drug Design: HIV-1 Protease


                           Celia Schiffer (UMass Medical School)

                           The Interdependency of Drug Resistance Evolution and Drug Design:  HIV-1 Protease, a Case Study


                           T. Whitfield (UMass Medical School)

                           Mechanistic Characterization of Inhibitor Resistance in HIV-1 Protease via Machine Learning and Atomistic Simulation


                           Celia Schiffer (UMass Medical School)

                           Interdependence of Inhibitor Recognition in HIV-1 Protease


Session VIII: Imaging Infection; Session Chair: Angela Gronenborn


3:30 – 4:00       Collin Kieffer (NIAID Invited Speaker; Caltech)

                           Multiscale Imaging of HIV Spread in Animal Models


4:00 – 4:30       João Mamede (Selected Poster Talk; Northwestern University)

                           Live Cell Imaging of HIV-1 Reverse Transcription


4:30 – 5:00       Gregory Melikyan (Selected Poster Talk; Emory University)

                           Loss of Capsid Protein and the Nuclear Membrane is a Pre-Requisite for Translocation of HIV-1 Pre-Integration Complexes into the Nucleus


5:00                   ADJOURN MEETING





Mark Your Calendars!


Structural Biology Related to HIV/AIDS – 2018


Thursday June 28 – Friday June 29, 2018


Natcher Conference Center, Bethesda, Maryland

Version: 2.0.0