Morning Welcome

8:45 a.m.

Welcome and Introductions, Dr. Lara Abramowitz, NIDDK & Dr. Tongzhong Ju, FDA Co-Chairs

Session I, Glyco Analytics & Chemistry

1hr 30min

Chair, Dr. Mark Lowenthal, Chemist, NIST

9:00 a.m., Rapid and reproducible imaging mass spectrometry workflows for detecting glycans in tissues, cells and biofluids

Dr. Richard Drake, Professor, Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina

9:30 a.m., Genetically encoded fluorescent biosensors for nucleotide sugars

Dr. Hui-wang Ai, Associate Professor, Department of Molecular Physiology and Biological Physics, School of Medicine, University of Virginia

10:00 a.m., Applications of glycan microarray technology to antibody research

Dr. Jeffrey Gildersleeve, Senior Investigator, NCI, NIH

10:30 a.m.,   Break

Session II, Glycoproteomics

1hr 30min

Chair, Dr. Aleksandra Nita-Lazar, Senior Investigator & Chief, Functional Cellular Networks Section, NIAID

10:45 a.m., CellSurfer: A Platform for Semi-Automated, Quantitative Discovery of Cell Surface N-Glycoproteins from Human Primary Cells

Dr. Rebekah Gundry, Professor and Vice Chair, Department of Cellular and Integrative Physiology, University of Nebraska Medical Center

11:15 a.m., Machine learning methods for clinical glycoproteomics and beyond

Dr. Heather Desaire, Professor, Department of Chemistry, University of Kansas

 11:45 a.m., Glycopeptide quantification and structural resolution

Dr. Radoslav Goldman, Professor, Department of Oncology & Department of Biochemistry and Molecular & Cellular Biology; Proteomics Shared Resource, Georgetown University

Lunch (12:15 p.m.) and GlyGen Demo (1 p.m.)


12:15 p.m., Lunch

1:00 p.m., Demonstration of new Glycoscience informatics tools by the NIH Common Fund GlyGen Program

Session III, Glycobiology of Disease and Therapeutics

1hr 20min

Co-Chairs Dr. Lara Abramowitz, NIDDK, NIH & Dr. Tongzhong Ju, OBP, CDER, FDA

 1:30 p.m., Manufacturing biotherapeutics with defined glycosylation to control their quality and safety

Dr Tongzhong Ju, Office of Biotechnology Products, Center for Drug Evaluation and Research, FDA

 1:50 p.m., Small molecule inhibition of the oligosaccharyl tansferase

Dr. Joseph Contessa, Professor of Therapeutic Radiology and of Pharmacology; Co-Leader, Radiobiology and Radiotherapy, Yale Cancer Center

 2:20 p.m., Siglec mediated regulation of immune responses

Dr. James Paulson, Professor and Co-Chair Department of Molecular Medicine, The Scripps Research Institute

Session IV, Human Milk Oligosaccharides

1hr 30 min

Chair, Dr. Michelle Bond, Program Director, NIGMS, NIH

3:00 p.m., The role of human milk oligosaccharides in the pathogenesis and treatment of necrotizing enterocolitis

               Dr. David J. Hackam, Surgeon-in-Chief, Professor of Surgery, Johns Hopkins Children's Center

3:30 p.m., Application of the membrane permeabilizing ability of HMOs

                Dr. Steven Townsend, Assistant Professor of Chemistry, Vanderbilt University

4:00 p.m., Investigating HMO – Enteric Virus Interactions: From Bench to Bedside and Beyond

                Dr. Sasirekha Ramani, Assistant Professor, Baylor College of Medicine

4:30 p.m., Closing remarks Dr. Lara Abramowitz, NIDDK & Dr. Tongzhong Ju, FDA

4:45 p.m., Meeting Chairs: Announcement of Abstract Awards

5:00 p.m., Adjourn

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