Agenda

NIH Common Fund Glycoscience Program Annual Meeting

06/16/2020 - 06/17/2020 Agenda for June 16, 2020

June 16, 2020

Welcome & Opening Remarks

10:00 a.m., EDT        Welcome & NIH Common Fund Update, OD NIH

Session I – Methods, Tools & Technologies

Glycoscience data integration, and analysis tools

Chair, Dr. Douglas Sheeley, OD

10:15 a.m.,  GlyGen - Glycoscience data integration: Data acquisition and standardization

                            Dr. Michael Tiemeyer, University of Georgia and Dr. Raja Mazumder, George Washington University

11:15 a.m.,        Round table discussion 

11:45 a.m.,        Break (45mins)

Session II – Methods, Tools & Technologies

Chair, Dr. Pamela Marino, NIGMS          

12:30 p.m.,        BapaFPs: Genetically encoded fluorescent indicators to image live-cell nucleotide sugars

                             Dr. Huiwang Ai, University of Virginia

12:40 p.m.,        Tuning and Tagging the O-GlcNAc Modification

                             Dr. Natasha Zachara, Johns Hopkins University   

12:50 p.m.,        New Tools for Studying GlcNAc Biology

                             Dr. Jennifer Kohler, UT Southwestern Medical Center

1:00 p.m.,           Tools to Facilitate Manipulation of Protein-Specific Glycosylation Stoichiometry in Cells

                             Dr. Christina Woo, Harvard University

1:10 p.m.,          Cell-Based Sensors and Drug-Like Modulators Targeting ppGalNAc-Transferases

                             Dr. Adam Linstedt, Carnegie-Mellon University

1:20 p.m.,          Tools to enable non-specialists to model glycoconjugates and glycan protein interactions 

                             Dr. Robert Woods,  University of Georgia

1:30 p.m.,          Catalytic Methods for Building Block Assembly and for Stereoselective Glycosylation

                             Dr. John Montgomery and Dr. Pavel Nagorny, University of Michigan

1:40 p.m.,          Refinement and implementation of the automated oligosaccharide synthesizer

                             Dr. Alexei Demchenko* and Dr. Keith Stine, University of Missouri St Louis; Cristina De Meo, Southern Illinois University, Edwardsville

1:50 p.m.,          Reagent Control for Stereoselective Glycosylation Reactions

                             Dr. Clay Bennett, Tufts University

2:00 p.m.,          Streamlining the chemoenzymatic synthesis of asymmetrical glycans of biological importance

                             Dr. Geert-Jan Boons, University of Georgia

2:10 p.m.,           Break

Session II – Methods, Tools & Technologies (cont.)

Polysaccharide Synthesis and Tools

3:00 p.m.,          Metabolic carbohydrate cell wall probes for bacterial structure and immune recognition studies

                             Dr. Catherine Leimkuhler Grimes, University of Delaware3:10 p.m.,         

3:10 p.m.,          Integrating Microbial Glycan Arrays with Genomic Sequences to Study Host Microbe Interactions

                             Dr. Sean Stowell, Emory University & Dr. Richard Cummings

3:20 p.m.,          Mining the Oral Microbiome for Novel Glycan-Binding Molecules

                             Dr. Stefan Ruhl, State University of New York Buffalo and Dr. Paul Sullam, University of California                                     San Francisco & San Fransisco Veterans Adminsitration Meidcal Center 

3:30 p.m.,          Chemoenzymatic synthesis of bacterial polysaccharides

                             Dr. Hai Yu* University of California Davis, Dr. Laura Kiessling, Massachusetts Institute of Technology,                               Dr. Lei Li, Georgia State  University   

3:40 p.m.,          Novel Methods and Technologies for Synthesis of Biomedically Relevant Carbohydrates

                             Dr. David Crich, University of Georgia, Dr. Peter Andreana University of Toledo 

3:50 p.m.,          Development of Multifunctional Probes for Profiling Microbial Glycans

                             Dr. Laura Kiessling* and Dr. Barbara Imperiali, Massachusetts Institute of TechnologySession V –

Methods, Tools & Technologies

GlyGen Demonstration Sessions

Chair, Dr. Amanda Melillo, NIDCR

4:00 – 4:45p.m. GlyGen Informatics Demos – choice one of the following to join

Session A. Use case discussions and data deposition: This session will explore the needs of the community, desires for the future development of the GlyGen resource, and mechanisms for the community to provide data to GlyGen.

Session B. GlyGen Features Demonstration: If you are unfamiliar with what GlyGen can do, this session will provide an overview of its functionalities and features and opportunities to ask how it can help you achieve your research goals.

Session C. Glycan ontology (GNOME), substructure searches and motifs: Another way to organize glycan structural diversity and identify glycoproteins with shared glycosylation motifs is to establish informatic relationships between glycans. This session will explore recent advances in representing and searching for glycan structural features.

5:00 – 5:45p.m. GlyGen Informatics Demos – choice one of the following to join

Session A. Use case discussions and data deposition: This session will explore the needs of the community, desires for the future development of the GlyGen resource, and mechanisms for the community to provide data to GlyGen.

Session B. GlyGen Features Demonstration: If you are unfamiliar with what GlyGen can do, this session will provide an overview of its functionalities and features and opportunities to ask how it can help you achieve your research goals.

Session C. Glycan ontology (GNOME), substructure searches and motifs: Another way to organize glycan structural diversity and identify glycoproteins with shared glycosylation motifs is to establish informatic relationships between glycans. This session will explore recent advances in representing and searching for glycan structural features.

6:00  p.m.            Day 1 wrap up comments

(3:00 p.m. West Coast)

 

 

 

 


Day 2, NIH Common Fund Glycoscience Program Annual Meeting

06/16/2020 - 06/17/2020 Agenda for Day 2

June 17, 2020

Session IV – Methods, Tools & Technologies

Affinity Probes, Libraries, & Screens

Chair, Dr. Preethi Chander, NIDCR

10:00 a.m.,        Ganglioside Interactome Toolkit

                             Dr. Ronald Schnaar, Johns Hopkins University 

10:10 a.m.,        Multiplex Luminex glycan array for large scale analyses of glycan-binding proteins      

                             Dr. Jin-Xiong She, Georgia Reagents Research Institute Inc

10:20 a.m.,        Adapting multiplex microspheres to analyze glycosylation features by flow cytometry

                             Dr. Loretta Yang, Lectenz Bio (formerly Glycosensors and Diagnostics)

Glycosaminoglycans & Glycolipids

10:30 a.m.,        Facile chemoenzymatic synthesis and purification of glycolipids

                             Dr. Xi Chen* UC Davis; and Dr. Jun Yin, Georgia State University

10:40 a.m.,        Tool for Predicting Glycosaminoglycan Recognition of Proteins

                             Dr. Umesh Desai, Virginia Common-Wealth University 

10:50 a.m.,        A Fluorescence-Based High-Throughput Platform for Glycotyping the Hematopoetic Cell Lineage

                             Dr. Hannes Buelow & Dr. Ulrich Steidl, Albert Einstein College of Medicine Inc           

11:00 a.m.,        Sequencing Glycosaminoglycans using Recognition Tunneling Nanopores

                             Dr. Xu Wang, Arizona State University                       

11:10 a.m.,        An Automated Platform for the CE-MS Analysis of Glycosaminoglycans

                             Dr. Jonathan Amster, University of Georgia

11:20 a.m.,         Expedited Synthesis of Glycosaminoglycans Containing Defined Sulfation Domains

                             *Dr. Linda Hsieh-Wilson, California Institute of Technology & *Dr. Jian Liu, University of North Carolina

Session VI – Methods, Tools & Technologies

Glycan Analysis: Progress Towards Facile Glycoproteomics

Chair, Dr. Karl Krueger, NCI

11:30 a.m.,        Simplified Glycan Profiling Workflows of Captured Immune Glycoproteins and Cells

                             Dr. Richard Drake, Dr. Peggy Angel, Dr. Anand Mehta, Medical University of South Carolina

11:40 a.m.,        Multiplex Chemical Tags for High Throughput Glycan and Glycopeptide Quantitation and Characterization  

                             Dr. Lingjun Li, University of Wisconsin

11:50 a.m.,        GlyProbity: tools to curate glycan structure pre and post deposition in the PDB

                             Dr. Robert Woods, Dr. Lachele Foley*, University of Georgia & Dr. Jasmine Young, Rutgers University

12:00 p.m.,        Shaping MSn technology for high impact glycan sequencing

                             Dr. Vernon Reinhold, University of New Hampshire

12:10 p.m.,        GlycoMiR: Mapping the miRNA-glycogene interactome

                             Dr. Lara Mahal, Dr. Daniela Buccella, New York University           

12:20 p.m.,        An open source software suite for processing glycomics and glycoproteomics mass spectral data

                             Dr. Joseph Zaia, Boston University Medical Campus

12:30 p.m.,        LC-MS Analysis of Site Specific Protein Glycoforms

                             Dr. Rado Goldman, Georgetown University

12:40 p.m.,        Mitogenic and oncogenic regulation of ERK/RSK signaling

                             * Dr. Bethany Eleanor Schaffer, and Dr. John Blenis, Weill Medical College of Cornell University

12:45 p.m.,        Lunch

Closed Session

Session III – Methods, Tools & Technologies 

Chemical Catalysis

Chair, Dr. Nikki Pohl, Indiana University

1:30 p.m.            Sugar Building Blocks and Automated Synthesis of Biomedically-Relevant Glycans

                             Dr. Nicola Pohl, Indiana University

1:40 p.m.            New Catalytic Methods for the Synthesis of Biomedically Relevant Carbohydrates

                             Dr. Maciej Walczak, University of Colorado

1:50 p.m.            Development of novel approaches for stereoselective construction of glycosidic linkages

                             Dr. Liming Zhang* University of California Santa Barbara, and Dr. Jianglong Zhu, University of Toledo

2:00 p.m.            Catalytic Methods for Stereoselective 1,2-Cis Glycosylation

                             Dr. Hien Nguyen, Wayne State University

2:10 p.m.            Develop Catalytic Methods to Streamline the Assembly of Oligosaccharides

                             Dr. Weiping Tang, University of Wisconsin-Madison               

2:20 p.m.           Transformative Methods for the Solid Phase Synthesis of Oligosaccharides

                            Dr. Matthew Brichacek, University of Maine Orono

2:30 p.m.            Round Table Discussion

3:00 p.m.            Meeting Warp up & Adjourn

Closed Executive Session

3:00 p.m.            Discussion (Consultants & Staff) 

 

 

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