Agenda

Coronaviruses, SARS-CoV-2, & Glycans

1-5:00 p.m., EDT, WebEx link & Agenda will be emailed to registrants on April 30
05/01/2020 CF-GSP Workshop via WebEx

Videocast:  https://videocast.nih.gov/summary.asp?live=37543&bhcp=1

Live closed captioning: https://livewrite-ncc.appspot.com/attend?event=cit003

Coronavirus Host Receptor(s) 

1:00 p.m., Dr. Tom Gallagher, Professor, Department of Microbiology and Immunology, Loyola University. Distinct Roles for Sialoside & Protein Receptors in Coronavirus Infection https://mbio.asm.org/content/11/1/e02764-19 

1:15 p.m., Dr. Somasekar Seshagiri, Co-founder and Chief Scientific Office, ModMab Therapeutics, Foster City, CA & Dr. Natalia Jura, Associate Professor, Department of Cellular and Molecular Pharmacology, University of California San Francisco. Human ACE2 receptor polymorphisms predict SARS-CoV-2 susceptibility  doi: https://doi.org/10.1101/2020.04.07.024752

1:35 p.m., Dr. M. Gordon Joyce, Chief, Structural Biology, The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., In support of the US Military HIV Research Program (MHRP) and Emerging Infectious Diseases Branch (EIDB), Walter Reed Army Institute of Research (WRAIR) A Cryptic Site of Vulnerability on the Receptor Binding Domain of the SARS-CoV-2 Spike Glycoprotein doi: https://doi.org/10.1101/2020.03.15.992883

1:50 p.m., Dr. Robert Linhardt, Ann and John H. Broadbent, Jr. ’59 Senior Constellation Professor of Biocatalysis and Metabolic Engineering, Chemistry and Chemical Biology, Rensselaer Polytechnic Institute. Glycosaminoglycan binding motif at S1/S2 proteolytic cleavage site on spike glycoprotein may facilitate novel coronavirus (SARS-CoV-2) host cell entry doi: https://doi.org/10.1101/2020.04.14.041459

2:05p.m., Dr. Geert-Jan Boons, Franklin Professor, Department of Chemistry, Complex Carbohydrate Research Center, University of Georgia. Probing Receptor and Co-Receptor specificities of Betacoronaviruses using Glycoarrays

SARS-CoV-2 Infection & the Immune Response  

2:20 p.m.,  Dr. Galit Alter, Professor of Medicine, Harvard Medical School & Group Leader, Ragon Institute of MGH, MIT and Harvard. Could antibody-glycosylation be the key to protective immunity to SARS-CoV-2?

2:35 p.m., Dr. Daniel Jacobson, Chief Scientist for Computational Systems Biology, Oak Ridge National Laboratory. Functional Immune Deficiency Syndrome via Intestinal Infection in COVID-19 doi:https://doi.org/10.1101/2020.04.06.028712

2:50 p.m., Dr. Laura Kiessling, Novartis Professor of Chemistry, Massachusetts Institute of Technology. Lectins as Probes of Glycosylation

SARS-CoV-2 Spike Glycoprotein: 3D Models & to MD Simulations with Glycosylation   

3:05 p.m., Dr. Max Crispin, Professor of Glycobiology, University of Southampton, UKSite-specific analysis of the SARS-CoV-2 glycan shield  doi:https://doi.org/10.1101/2020.03.26.010322                                                                                                                                                    

3:20 p.m., Dr. Robert Woods, Professor, Department of Biochemistry and Molecular Biology, Complex Carbohydrate Research Center, University of Georgia. 3D Models of glycosylated SARS-CoV-2 spike protein suggest challenges and opportunities for vaccine development https://www.biorxiv.org/content/10.1101/2020.04.07.030445v1

3:35 p.m., Dr. Parastoo Azadi, Senior Research Scientist & Technical Director-Analytical Services, Complex Carbohydrate Research Center, University of Georgia. Deducing the N- and O- glycosylation profile of the spike protein of novel coronavirus SARS-CoV-2 https://doi.org/10.1101/2020.04.01.020966

3:50 p.m., Dr. Elisa Fadda, Assistant Professor, Department of Chemistry & Hamilton Institute, Maynooth University, IrelandInsight on the structure and dynamics of the SARS-CoV2-S glycoprotein from MD simulations 

Round Table Discussion Leaders

Dr. Joseph J Barchi Jr, Head, Glycoconjugate & NMR Section, Chemical Biology Laboratory, Center for   Cancer Research, NCI

Dr. Heather Desaire, Professor, Department of Chemistry, University of Kansas, Lawrence Campus

Dr. Catherine Grimes, Professor, Department of Chemistry and Biochemistry, University of Delaware

Dr. James C. Paulson, Cecil H. and Ida M. Green Chair of Chemistry, Co-chair Professor Department of   Molecular Medicine, Scripps Research

Dr. Ashutosh Rao, Chief, Laboratory of Biochemistry, Division of Biotechnology Review and Research III, Office of Biotechnology Products, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, FDA

Dr. Sean Stowell, Assistant Professor of Pathology and Laboratory Medicine, Emory University School of Medicine

Dr. Joseph Zaia, Professor, Department of Biochemistry, Boston University College of Medicine 

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