Agenda

Quantitative and Systems Pharmacology Workshop II

09/09/2010 - 09/10/2010
QUANTITATIVE & SYSTEMS PHARMACOLOGY WORKSHOP II
Lister Hill Auditorium
National Institutes of Health
Bethesda, Maryland
September 9-10, 2010
 
 
Thursday, September 9
Day 1
7:30 am    Poster Session Opens
 
8:15 am     Welcome and Introduction
                  Jeremy Berg, Director, NIGMS
  
                  Meeting Overview
                 Michael Rogers, NIGMS
 
Session I
Session Chair:  Richard Lalonde, Pfizer, Inc.
 
8:30 am    Perspective 1: “Applying Systems Biology Concepts
                  to Pharmacological Problems”
    Peter Sorger, Harvard Medical School
 
8:50 am    “A Chemical Lens on Pharmacological Networks”
    Brian Shoichet, University of California, San Francisco
 
         9:25 am     "Modeling of Aβ Dynamics in Animals and Humans" 
                            Julie Stone, Merck Research Labs  
   
         10:00 am   BREAK    
 
         10:30 am   “Mechanistic Modeling Approaches in Population PKPD”
                             Paul Jasper, RES Group Inc.
 
11:05 am   “Occupancy-driven Cell Signaling Model of CD20
                    Agonists to Predict Combination Chemotherapy
                   in Mice”
     Don Mager, University of Buffalo
 
11:40am   “Applying Engineering Principles to the Development
                   of Novel Cancer Therapies”
     Birgit Schoeberl, Merrimack Pharmaceuticals
 
12:15pm   LUNCH(on your own, campus cafeterias available)
                Poster Session Continues
 
Session II
Session Chair: David D’Argenio, University of Southern
                        California
 
1:15 pm   “Pharmacodynamics of Pacitaxel by Intravital Imaging in Mice”
     Tim Mitchison, Harvard Medical School
 
1:50 pm   “Application of Drug-Disease Models in the Development of
                  Anti-Diabetic Agents”
    Jenny Chien, Eli Lilly and Company
 
2:25 pm Lightning Talks
               (Five-minute, two-slide presentations from
               six selected poster presenters)
 
Aurel Cami, Children’s Hospital Boston
Matthew Riggs, Metrum Institute and Biogen Idec
Alison Harrill, North Carolina State University and
 University of  North Carolina
Oleg Demin, Institute for Systems Biology, Moscow
Cornelia Landersdorfer, Ordway Research Institute
Sharat Vayttaden, University of Texas Health          
Sciences Center
 
3:00 pm   BREAK
 
4:00 pm   “Transporter Systems in Drug Disposition and 
                   Response”
   Kathleen Giacomini, University of California, San
   Francisco
 
4:35 pm   Perspective 2
               “Modeling Applications in Drug Development”
   Richard Lalonde, Pfizer, Inc.
 
4:55pm    Panel Discussion: Training Needs, Opportunities and
                 Barriers 
   Richard Lalonde and Russ Altman, Moderators
 
 
Friday, September10
Day 2
 
Session III
Session Chair: Sandra Allerheiligen, Merck, Inc.
 
          8:10 am    Perspective 3: "Leveraging Quantitative and Systems
                             Pharmacology in Drug Development: Enabling
                             Decisions”
    Sandra RB Allerheiligen, Merck, Inc.
 
8:30 am    “Discovering Master Regulators of Human
                   Malignancies and their Chemical
                   Modulators via an Integrated Systems Biology    
                   Approach.”
   Andrea Califano, Columbia Medical School
 
          9:05 am    “Systems Pharmacology: Bridging PKPD
                            and Systems Biology in Drug Discovery" 
                           Piet Van der Graaf, Pfizer, Inc. 
 
9:40 am   BREAK
 
10:30 am “Screening and Rational Design Approaches for 
                  Developing Selective and Non-Selective Protein    
                  Kinase Inhibitors”
                 Nathanael Gray, Dana Farber/ Harvard University   
 
11:05 am “Cellular Heterogeneity in Models of Cancer and 
                  Metabolism: Which Differences Make a 
                  Difference?”
     Lani Wu, Southwestern Medical College
 
11:40 am “Quantitative Drug-Disease Trial Models: Vision
                   2020”
     Yaning Wang, Food and Drug Administration
 
12:15 pm  LUNCH (on your own, campus cafeterias 
                   available)
 
1:00 pm   Poster Session Concludes
 
          Session IV
          Session Chair: Russ Altman, Stanford University
 
1:15 pm     “Human Interactomes in Physiology and Disease” 
     Marc Vidal, Dana Farber
 
1:50 pm    "Systems Pharmacology and Insulin Resistance"
                 Shankar Subramaniam, University of California, 
                 San Diego
 
2:25 pm     “Combining Networks of Genes, 
                  Small Molecules and Phenotypes
                  to Understand and Predict Drug Action”
                  Russ Altman, Stanford University
 
3:00 pm     Panel Discussion: Research Needs, Opportunities 
                   and Barriers
                 David D’Argenio and Peter Sorger, Moderators
 
3:30 pm    Closing remarks
                Co-Chairs
 
 
 
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